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Article

Hst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56.

The Journal of biological chemistry - 28 Dec 2007

Thaminy Safia, Newcomb Benjamin, Kim Jessica, Gatbonton Tonibelle, Foss Eric, Simon Julian, Bedalov Antonio

Abstract excerpt

The SIR2 homologues HST3 and HST4 have been implicated in maintenance of genome integrity in the yeast Saccharomyces cerevisiae. We find that Hst3 has NAD-dependent histone deacetylase activity in vitro and that it functions during S phase to deacetylate the core domain of histone H3 at lysine 56 (H3K56). In response to genotoxic stress, Hst3 undergoes rapid Mec1-dependent phosphorylation and is targeted for...

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PMID: 17977840
DOI: 10.1074/jbc.M706384200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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