Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ABC Multidrug Transporters: Structure, Function and Role in Chemoresistance

21 Dec 2007

Abstract excerpt

Three ATP-binding cassette (ABC)-superfamily multidrug efflux pumps are known to be responsible for chemoresistance; P-glycoprotein (ABCB1), MRP1 (ABCC1) and ABCG2 (BCRP). These transporters play an important role in normal physiology by protecting tissues from toxic xenobiotics and endogenous metabolites. Hydrophobic amphipathic compounds, including many clinically used drugs, interact with the substrate-binding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotics Pharmacokinetics and Efficacy
Share to Drug Transport and Resistance Mechanisms
Share to Pharmacological Effects and Toxicity Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18154452
DOI: 10.2217/14622416.9.1.105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ABC Multidrug Transporters: Structure, Function and Role in ChemoresistancePMID 18154452Read ↗

Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters.Semantic proximity Read ↗

ATP‐binding cassette (ABC) transporters in cancer: A review of recent updatesSemantic proximity Read ↗

Clinically-Relevant ABC Transporter for Anti-Cancer Drug ResistanceSemantic proximity Read ↗

Pharmacogenomics of ABC transporters and its role in cancer chemotherapy.Semantic proximity Read ↗

ABC transporter superfamily. An updated overview, relevance in cancer multidrug resistance and perspectives with personalized medicineSemantic proximity Read ↗

Pharmacogenetics of ATP-binding cassette transporters in cancer and chemotherapy.Semantic proximity Read ↗

ATP Binding Cassette Transporters and Cancer: Revisiting Their Controversial RoleSemantic proximity Read ↗

Importance of ABCC1 for cancer therapy and prognosisSemantic proximity Read ↗

Pharmacogenetics of ATP-binding cassette transporters and clinical implications.Semantic proximity Read ↗

ABC transporters and the hallmarks of cancer: roles in cancer aggressiveness beyond multidrug resistanceSemantic proximity Read ↗

Mechanisms of resistance to anticancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2Semantic proximity Read ↗

Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.