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Article

Human Multidrug Resistance ABCB and ABCG Transporters: Participation in a Chemoimmunity Defense System

1 Oct 2006

Abstract excerpt

In this review we give an overview of the physiological functions of a group of ATP binding cassette (ABC) transporter proteins, which were discovered, and still referred to, as multidrug resistance (MDR) transporters. Although they indeed play an important role in cancer drug resistance, their major physiological function is to provide general protection against hydrophobic xenobiotics. With a highly conserved...

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PMID: 17015488
DOI: 10.1152/physrev.00037.2005

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