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Article

Paradoxical urinary phenytoin metabolite (S)/(R) ratios in CYP2C191/2 patients.

Epilepsy research - 1 Sept 2006

Argikar Upendra A, Cloyd James C, Birnbaum Angela K, Leppik Ilo E, Conway Jeannine, Kshirsagar Smita, Oetting William S, Klein Erin C, Remmel Rory P

Abstract excerpt

Phenytoin (PHT) is primarily metabolized to 5-(4'-hydroxyphenyl)-5-phenylhydantoin (p-HPPH), accounting for 67-88% of an administered dose in humans. p-HPPH is formed by the cytochrome (CYP) 450 enzymes CYP2C9 and CYP2C19, then glucuronidated and excreted into the urine. CYP2C9 catalyses the prochiral formation of (R) and (S)-p-HPPH, and is approximately 40 times more stereoselective towards the formation of the...

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Source

Identifiers

PMID: 16815679
DOI: 10.1016/j.eplepsyres.2006.05.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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