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[Association between genetic polymorphisms of CYP2C19 and CYP2C9 and phenytoin serum concentration].

Zhonghua yi xue za zhi - 17 Oct 2004

Huang Yue, Yang Jing-Fang, Qi Xiao-Lian, Wang Yu-Qin, Wang Wei-Zhi, Chen Biao

Abstract excerpt

OBJECTIVE: To investigate the relationship between the genetic polymorphism of cytochrome CYP2C19 and CYP2C9 and the serum concentration of phenytoin (PHT) in patients with epilepsy. METHODS: The peripheral blood samples of 200 patients with epilepsy aged 2 - 68, were collected to undergo PCR. Denaturing high performance liquid chromatography (DHPLC) was used to detect the PCR products so as to examined the 2...

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Aryl Hydrocarbon Hydroxylases
Child, Preschool
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP2C9
Epilepsy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mixed Function Oxygenases

Polymerase Chain Reaction

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PMID: 15569425

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