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Article

Assessment of urinary mephenytoin metrics to phenotype for CYP2C19 and CYP2B6 activity.

European journal of clinical pharmacology - 1 Apr 2008

Klaassen Tobias, Jetter Alexander, Tomalik-Scharte Dorota, Kasel Dirk, Kirchheiner Julia, Jaehde Ulrich, Fuhr Uwe

Abstract excerpt

OBJECTIVES: (S)-Mephenytoin is selectively metabolised to (S)-4'-hydroxymephenytoin by CYP2C19. The urinary excretion of 4'-hydroxymephenytoin reflects the activity of individual enzymes. We evaluated fractioned urinary collection and beta-glucuronidase pre-treatment in order to determine the optimal CYP2C19 metrics. We also assessed whether urinary excretion of N-desmethylmephenytoin (nirvanol) might be a useful...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2B6

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Source

Identifiers

PMID: 18071681
DOI: 10.1007/s00228-007-0416-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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