Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CYP2C91B promoter polymorphisms, in linkage with CYP2C192, affect phenytoin autoinduction of clearance and maintenance dose.

The Journal of pharmacology and experimental therapeutics - 1 Feb 2010

Chaudhry Amarjit S, Urban Thomas J, Lamba Jatinder K, Birnbaum Angela K, Remmel Rory P, Subramanian Murali, Strom Stephen, You Joyce H, Kasperaviciute Dalia, Catarino Claudia B, Radtke Rodney A, Sisodiya Sanjay M, Goldstein David B, Schuetz Erin G

Abstract excerpt

The commonly prescribed antiepileptic drug phenytoin has a narrow therapeutic range and wide interindividual variability in clearance explained in part by CYP2C9 and CYP2C19 coding variants. After finding a paradoxically low urinary phenytoin metabolite (S)/(R) ratio in subjects receiving phenyto...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticoagulants
Share to Anticonvulsants

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C9

Share to Enzyme Induction

Share to Hep G2 Cells

Share to Microsomes, Liver

Share to Phenytoin

Share to Warfarin

Source

Open in PubMed Open full text

Identifiers

PMID: 19855097
DOI: 10.1124/jpet.109.161026
PMCID: PMC2812115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19855097-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose.PMID 19855097Read ↗

Phenytoin metabolic ratio: a putative marker of CYP2C9 activity in vivo.Semantic proximity Read ↗

Paradoxical urinary phenytoin metabolite (S)/(R) ratios in CYP2C19*1/*2 patients.Semantic proximity Read ↗

Influence of the CYP2C9 AND CYP2C19 polymorphisms on phenytoin hydroxylation in healthy individuals from south India.Semantic proximity Read ↗

Contributions of CYP2C9/CYP2C19 genotypes and drug interaction to the phenytoin treatment in the Korean epileptic patients in the clinical setting.Semantic proximity Read ↗

Dosage recommendation of phenytoin for patients with epilepsy with different CYP2C9/CYP2C19 polymorphisms.Semantic proximity Read ↗

Genetic polymorphisms and functional characterization of the 5'-flanking region of the human CYP2C9 gene: in vitro and in vivo studies.Semantic proximity Read ↗

The predictive value of MDR1, CYP2C9, and CYP2C19 polymorphisms for phenytoin plasma levels.Semantic proximity Read ↗

CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects.Semantic proximity Read ↗

CYP2C9 polymorphisms in epilepsy: influence on phenytoin treatmentSemantic proximity Read ↗

Population Estimation of the Effects of Cytochrome P450 2C9 and 2C19 Polymorphisms on Phenobarbital Clearance in JapaneseSemantic proximity Read ↗

The effect of polymorphic metabolism enzymes on serum phenytoin level.Semantic proximity Read ↗

CYP2C19 genotype determines enzyme activity and inducibility of S-mephenytoin hydroxylase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.