Article
Prostate cancer susceptibility is mediated by interactions between exposure to ultraviolet radiation and polymorphisms in the 5' haplotype block of the vitamin D receptor gene.
Cancer letters - 18 Mar 2007
Rukin Nicholas J, Luscombe Christopher, Moon Sam, Bodiwala Dhaval, Liu Samson, Saxby Mark F, Fryer Anthony A, Alldersea Julie, Hoban Paul R, Strange Richard C
Abstract excerpt
Vitamin D receptor (VDR) polymorphisms are prostate cancer risk candidates. We determined if SNPs in haplotype block sub-regions C2 (SNPs C2-1, G/C(3436), C2-2, A/G(3944)) or C1 (C1-1, C/T(20965), C1-2, C/T(30056)) are associated with risk in an ultraviolet radiation (UVR)-dependent manner. In men with very low exposure, SNPs in both sub-regions were associated with risk. Various haplotypes in haplotype block C...
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