Article
Genetic variants in the vitamin d receptor are associated with advanced prostate cancer at diagnosis: findings from the prostate testing for cancer and treatment study and a systematic review.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2009
Chen Lina, Davey Smith George, Evans David M, Cox Angela, Lawlor Debbie A, Donovan Jenny, Yuan Wei, Day Ian N M, Martin Richard M, Lane Athene, Rodriguez Santi, Davis Michael, Zuccolo Luisa, Collin Simon M, Hamdy Freddie, Neal David, Lewis Sarah J
Abstract excerpt
Low levels of plasma vitamin D have been implicated as a possible risk factor for both prostate cancer incidence and advanced disease, and recent phase II trials suggest that vitamin D supplementation might delay progression of prostate cancer. Common polymorphisms in the vitamin D receptor (VDR) are associated with VDR activity and are therefore potentially useful proxies for assessing whether vitamin D is...
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