Article
Sequence variation within the 5' regulatory regions of the vitamin D binding protein and receptor genes and prostate cancer risk.
The Prostate - 1 Aug 2005
Kidd La Creis R, Paltoo Dina N, Wang Songping, Chen Weidong, Akereyeni Folasade, Isaacs William, Ahaghotu Chiledum, Kittles Rick
Abstract excerpt
BACKGROUND: The vitamin D receptor (VDR) and binding protein (DBP) mediate the cellular transport, activity, and anti-tumor action of 1,25-dihydroxyvitamin D3 [1,25-(OH)(2)D3]. The purpose of this investigation is to determine whether novel single nucleotide polymorphisms (SNPs) within the transcriptional regulatory regions of the VDR and DBP are associated with prostate cancer risk. METHODS: Novel SNPs were...
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