Article
Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, and prostate cancer: a nested case-control study.
Cancer causes & control : CCC - 1 Feb 2015
Gilbert Rebecca, Bonilla Carolina, Metcalfe Chris, Lewis Sarah, Evans David M, Fraser William D, Kemp John P, Donovan Jenny L, Hamdy Freddie C, Neal David E, Lane J Athene, Smith George Davey, Lathrop Mark, Martin Richard M
Abstract excerpt
PURPOSE: Vitamin D pathway single nucleotide polymorphisms (SNPs) are potentially useful proxies for investigating whether circulating vitamin D metabolites [total 25-hydroxyvitamin-D, 25(OH)D; 1,25-dihydroxyvitamin, 1,25(OH)2D] are causally related to prostate cancer. We investigated associations of sixteen SNPs across seven genes with prostate-specific antigen-detected prostate cancer. METHODS: In a nested...
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