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Article

Vitamin D receptor (VDR) gene polymorphisms and haplotypes, interactions with plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D, and prostate cancer risk.

The Prostate - 15 Jun 2007

Mikhak Bahar, Hunter David J, Spiegelman Donna, Platz Elizabeth A, Hollis Bruce W, Giovannucci Edward

Abstract excerpt

BACKGROUND: The vitamin D receptor (VDR) is required for actions of vitamin D. The binding of 1,25-dihydroxyvitamin D to the VDR on prostatic epithelial cells prompts the regulation of cancer-related genes. METHODS: We conducted a nested case-control study in the Health Professionals Follow-up Study to investigate the role of the VDR Cdx2, Fok1, and Bsm1 gene polymorphisms and associated haplotypes and their...

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PMID: 17440943
DOI: 10.1002/pros.20570

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VDR

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