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Article

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach.

Cell - 30 Jun 2006

Zender Lars, Spector Mona S, Xue Wen, Flemming Peer, Cordon-Cardo Carlos, Silke John, Fan Sheung-Tat, Luk John M, Wigler Michael, Hannon Gregory J, Mu David, Lucito Robert, Powers Scott, Lowe Scott W

Abstract excerpt

The heterogeneity and instability of human tumors hamper straightforward identification of cancer-causing mutations through genomic approaches alone. Herein we describe a mouse model of liver cancer initiated from progenitor cells harboring defined cancer-predisposing lesions. Genome-wide analyses of tumors in this mouse model and in human hepatocellular carcinomas revealed a recurrent amplification at mouse...

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Identifiers

PMID: 16814713
DOI: 10.1016/j.cell.2006.05.030
PMCID: PMC3026384

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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