Conversion of lysine 91 to methionine or glutamic acid in human choriogonadotropin alpha results in the loss of cAMP inducibility.

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Article

Conversion of lysine 91 to methionine or glutamic acid in human choriogonadotropin alpha results in the loss of cAMP inducibility.

The Journal of biological chemistry - 25 Sept 1991

Yoo J, Ji I, Ji T H

Abstract excerpt

Human choriogonadotropin (hCG) is a heterodimeric glycoprotein hormone. The alpha subunit comprises 92 amino acids, of which 6 are Lys residues (Morgan, F.G., Birken, S., and Canfield, R.E. (1975) J. Biol. Chem. 250, 5247-5258). Our photoaffinity-labeling studies indicate that several of these Ly...

Topics

Animals
Cell Line
Chorionic Gonadotropin
Cricetinae
Cricetulus
Cyclic AMP
DNA
Gene Expression
Glutamates
Glutamic Acid
Lysine
Methionine
Mice
Mutation
Radioimmunoassay
Swine
Transfection
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 1680852

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1680852-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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