Article
Mutations that induce constitutive activation and mutations that impair signal transduction modulate the basal and/or agonist-stimulated internalization of the Lutropin/Choriogonadotropin receptor.
The Journal of biological chemistry - 25 Dec 1998
Min K S, Liu X, Fabritz J, Jaquette J, Abell A N, Ascoli M
Abstract excerpt
Previous results from this laboratory suggested that the same active conformation of the lutropin/choriogonadotropin receptor (LHR) is involved in the stimulation of G proteins and in triggering the internalization of the bound agonist. We have now analyzed two naturally occurring, constitutively active mutants of the human LHR. These mutations were introduced into the rat LHR (rLHR) and are designated L435R and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.