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Article

Only a portion of the small seatbelt loop in human choriogonadotropin appears capable of contacting the lutropin receptor.

The Journal of biological chemistry - 22 Oct 2004

Bernard Michael P, Lin Win, Cao Donghui, Myers Rebecca V, Xing Yongna, Moyle William R

Abstract excerpt

Twenty residues of the human choriogonadotropin (hCG) beta-subunit that are wrapped around alpha-subunit loop 2 like a "seatbelt" stabilize the heterodimer and enable the hormone to distinguish lutropin (LHR), follitropin, and thyrotropin receptors. The N-terminal portion of the seatbelt contains a small disulfide-stabilized loop needed for heterodimer assembly and is thought to mediate hCG-LHR interactions. To...

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Source

Identifiers

PMID: 15304512
DOI: 10.1074/jbc.M406932200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Only a portion of the small seatbelt loop in human choriogonadotropin appears capable of contacting the lutropin receptor.PMID 15304512Read ↗

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