Recombinant carbohydrate variant of human choriogonadotropin beta-subunit (hCG beta) descarboxyl terminus (115-145). Expression and characterization of carboxyl-terminal deletion mutant of hCG beta in the baculovirus system.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Recombinant carbohydrate variant of human choriogonadotropin beta-subunit (hCG beta) descarboxyl terminus (115-145). Expression and characterization of carboxyl-terminal deletion mutant of hCG beta in the baculovirus system.

The Journal of biological chemistry - 5 Apr 1991

Chen W Y, Bahl O P

Abstract excerpt

A recombinant analog of human choriogonadotropin beta-subunit descarboxyl-terminal peptide (115-145 residues, delhCG beta) was obtained by the expression of corresponding beta cDNA in the baculovirus expression system. The efficiency of expression and secretion was high. The recombinant delhCG beta was purified by immunoaffinity using a specific monoclonal antibody against hCG beta and reverse phase high...

Topics

Baculoviridae
Carbohydrates
Chorionic Gonadotropin
Chromatography, High Pressure Liquid
Cyclic AMP
Electrochemistry
Electrophoresis, Polyacrylamide Gel
Gene Expression Regulation, Viral
Genes, Viral
Genetic Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Hydrolysis

Mutagenesis, Site-Directed

Mutation

Progesterone

Radioimmunoassay

Radioligand Assay

Recombinant Proteins

Source

Open in PubMed

Identifiers

PMID: 1848851

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1848851-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recombinant carbohydrate variant of human choriogonadotropin beta-subunit (hCG beta) descarboxyl terminus (115-145). Expression and characterization of carboxyl-terminal deletion mutant of hCG beta in the baculovirus system.PMID 1848851Read ↗

The biological role of the carboxyl-terminal extension of human chorionic gonadotropin [corrected] beta-subunit.Semantic proximity Read ↗

The LHbeta gene of several mammals embeds a carboxyl-terminal peptide-like sequence revealing a critical role for mucin oligosaccharides in the evolution of lutropin to chorionic gonadotropin in the animal phyla.Semantic proximity Read ↗

Homologous and heterologous carboxyl terminal peptide (CTP) linker sequences enhance the secretion of bioactive single-chain bovine LH analogs.Semantic proximity Read ↗

Single chain human chorionic gonadotropin, hCGalphabeta: effects of mutations in the alpha subunit on structure and bioactivity.Semantic proximity Read ↗

The six N-linked carbohydrates of the lutropin/choriogonadotropin receptor are not absolutely required for correct folding, cell surface expression, hormone binding, or signal transduction.Semantic proximity Read ↗

Unmasking a new recognition signal for O-linked glycosylation in the chorionic gonadotropin beta subunit.Semantic proximity Read ↗

Human chorionic gonadotropin with C-elongated alpha-subunit retains full receptor binding and partial agonist activity.Semantic proximity Read ↗

Conversion of lysine 91 to methionine or glutamic acid in human choriogonadotropin alpha results in the loss of cAMP inducibility.Semantic proximity Read ↗

Alteration of N-linked oligosaccharide structures of human chorionic gonadotropin beta-subunit by disruption of disulfide bonds.Semantic proximity Read ↗

On the role of the invariant glutamine at position 54 in the human choriogonadotropin beta subunit.Semantic proximity Read ↗

Human chorionic gonadotropin beta-subunit affects the folding and glycosylation of alpha-cys mutants.Semantic proximity Read ↗

Altered glycosylation of human chorionic gonadotropin decreases its hormonal activity as determined by cyclic-adenosine 3',5'-monophosphate production in MA-10 cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.