Article
Engineering human glycoprotein hormone superactive analogues.
Nature biotechnology - 1 Oct 1996
Szkudlinski M W, Teh N G, Grossmann M, Tropea J E, Weintraub B D
Abstract excerpt
We report the generation of superactive analogues of human glycoprotein hormones, with potential applications in thyroid and reproductive disorders. Current biological and structural data were used to rationalize mutagenesis. The 11-20 region in the alpha-subunit with a cluster of lysine residues...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Biotechnology
- Cell Line
- Chorionic Gonadotropin
- DNA Primers
- Drug Design
- Evolution, Molecular
- Glycoproteins
- Hormones
- Humans
- Models, Molecular
- Mutation
- Protein Conformation
- Protein Engineering
- Thyrotropin