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Article

Engineering human glycoprotein hormone superactive analogues.

Nature biotechnology - 1 Oct 1996

Szkudlinski M W, Teh N G, Grossmann M, Tropea J E, Weintraub B D

Abstract excerpt

We report the generation of superactive analogues of human glycoprotein hormones, with potential applications in thyroid and reproductive disorders. Current biological and structural data were used to rationalize mutagenesis. The 11-20 region in the alpha-subunit with a cluster of lysine residues forms a previously unrecognized domain critical for receptor binding and signal transduction, as well as an important...

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PMID: 9631089
DOI: 10.1038/nbt1096-1257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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