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Functional study of a recombinant form of human LHbeta-subunit variant carrying the Gly(102)Ser mutation found in Asian populations.

Molecular human reproduction - 1 Oct 2002

Lamminen Tarja, Jiang Min, Manna Pulak R, Pakarinen Pirjo, Simonsen Henrik, Herrera Rene J, Huhtaniemi Ilpo

Abstract excerpt

Genetic variants of human LH caused by amino acid replacements in the beta-subunit have been demonstrated to affect reproductive function. Occurrence of a G(1502)A substitution in the LHbeta gene leading to Gly(102)Ser replacement of the LHbeta protein has been found to be associated with infertility in the Singapore Chinese population. In the present study, a search for this LHbeta allele from 383 DNA samples...

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PMID: 12356936
DOI: 10.1093/molehr/8.10.887

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