Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.

doi:10.1523/JNEUROSCI.0746-06.2006

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Article

Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 28 Jun 2006

Dickey Chad A, Yue Mei, Lin Wen-Lang, Dickson Dennis W, Dunmore Judith H, Lee Wing C, Zehr Cynthia, West Gemma, Cao Songsong, Clark Amber M K, Caldwell Guy A, Caldwell Kim A, Eckman Christopher, Patterson Cam, Hutton Michael, Petrucelli Leonard

Abstract excerpt

Accumulation of the microtubule-associated protein tau into neurofibrillary lesions is a pathological consequence of several neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease. Hereditary mutations in the MAPT gene were shown to promote the formation of structurally distinct tau aggregates in patients that had a parkinsonian-like clinical presentation. Whether tau aggregates...

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Identifiers

PMID: 16807328
DOI: 10.1523/JNEUROSCI.0746-06.2006
PMCID: PMC6673930

Genes

MAPT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.PMID 16807328Read ↗

CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival.Semantic proximity Read ↗

<i>In vivo</i> evidence of CHIP up‐regulation attenuating tau aggregationSemantic proximity Read ↗

Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes.Semantic proximity Read ↗

Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIPSemantic proximity Read ↗

Loss of Tau results in defects in photoreceptor development and progressive neuronal degeneration in Drosophila.Semantic proximity Read ↗

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation.Semantic proximity Read ↗

U‐box protein carboxyl terminus of Hsc70‐interacting protein (CHIP) mediates poly‐ubiquitylation preferentially on four‐repeat Tau and is involved in neurodegeneration of tauopathySemantic proximity Read ↗

Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau PathologySemantic proximity Read ↗

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Evolutionarily conserved regulators of tau identify targets for new therapiesSemantic proximity Read ↗

CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo.Semantic proximity Read ↗

Phosphorylated tau and the neurodegenerative foldopathies.Semantic proximity Read ↗

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