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Article

Phosphorylated tau and the neurodegenerative foldopathies.

Biochimica et biophysica acta - 3 Jan 2005

Kosik Kenneth S, Shimura Hideki

Abstract excerpt

Many studies have implicated phosphorylated tau in the Alzheimer disease process. However, the cellular fate of phosphorylated tau has only recently been described. Recent work has shown that tau phosphorylation at substrate sites for the kinases Cdk5 and GSK3-beta can trigger the binding of tau to the chaperones Hsc70 and Hsp27. The binding of phosphorylated tau to Hsc70 implied that the complex may be a...

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Identifiers

PMID: 15615647
DOI: 10.1016/j.bbadis.2004.10.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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