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Article

<i>In vivo</i> evidence of CHIP up‐regulation attenuating tau aggregation

30 Jun 2005

Abstract excerpt

The carboxyl terminus of heat-shock cognate (Hsc)70-interacting protein (CHIP) is a ubiquitin E3 ligase that can collaborate with molecular chaperones to facilitate protein folding and prevent protein aggregation. Previous studies showed that, together with heat-shock protein (Hsp)70, CHIP can regulate tau ubiquitination and degradation in a cell culture system. Ubiquitinated tau is one component in...

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PMID: 16111477
DOI: 10.1111/j.1471-4159.2005.03272.x

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<i>In vivo</i> evidence of CHIP up‐regulation attenuating tau aggregationPMID 16111477Read ↗

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