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Article

CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival.

The Journal of biological chemistry - 6 Feb 2004

Shimura Hideki, Schwartz Daniel, Gygi Steven P, Kosik Kenneth S

Abstract excerpt

The microtubule-binding protein tau has been implicated in the neurofibrillary pathology of Alzheimer's disease. Within affected cells, ubiquitinated and hyperphosphorylated tau assembles into massive filamentous polymers. Eventually these tangle-bearing neurons die. The formation of neurofibrillary tangles closely parallels the progression and anatomic distribution of neuronal loss in Alzheimer's disease,...

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Identifiers

PMID: 14612456
DOI: 10.1074/jbc.M305838200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival.PMID 14612456Read ↗

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