Article
Polymorphisms in the DNA repair genes XPD (ERCC2) and XPF (ERCC4) are not associated with sporadic late-onset Alzheimer's disease.
Neuroscience letters - 1 Sept 2006
Dogru-Abbasoglu Semra, Inceoglu Muzeyyen, Parildar-Karpuzoglu Hande, Hanagasi Hasmet A, Karadag Berrin, Gurvit Hakan, Emre Murat, Aykac-Toker Gulcin, Uysal Mujdat
Abstract excerpt
Nucleotide excision repair (NER) is the most versatile mechanism of DNA repair, recognizing and dealing a variety of helix-distorting lesions. Xeroderma pigmentosum group D (XPD) and group F (XPF) are essential participants in NER pathway. There is evidence that two common polymorphisms of XPD gene (g.22541C>A; exon 6 and g.35931A>C; Lys>Gln; exon 23) may be associated with differential DNA repair activities....
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