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Article

Associations between DNA Damage, DNA Base Excision Repair Gene Variability and Alzheimer's Disease Risk.

Dementia and geriatric cognitive disorders - 1 Jan 2016

Kwiatkowski Dominik, Czarny Piotr, Toma Monika, Jurkowska Natalia, Sliwinska Agnieszka, Drzewoski Jozef, Bachurska Agnieszka, Szemraj Janusz, Maes Michael, Berk Michael, Su Kuan-Pin, Galecki Piotr, Sliwinski Tomasz

Abstract excerpt

BACKGROUND: Increased oxidative damage to DNA is one of the pathways involved in Alzheimer's disease (AD). Insufficient base excision repair (BER) is in part responsible for increased oxidative DNA damage. The aim of the present study was to assess the effect of polymorphic variants of BER-involved genes and the peripheral markers of DNA damage and repair in patients with AD. MATERIAL AND METHODS: Comet assays...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27011006
DOI: 10.1159/000443953

Genes

XRCC1
OGG1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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