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Article

Association of polymorphism of DNA repair gene XRCC1 with sporadic late-onset Alzheimer's disease and age of onset in elderly Han Chinese.

Journal of the neurological sciences - 15 Aug 2010

Qian Yun, Chen Weixian, Wu Jianqing, Tao Tong, Bi Liqing, Xu Wei, Qi Hanmei, Wang Yan, Guo Liwei

Abstract excerpt

Alzheimer's disease (AD) is characterized by the presence of beta-amyloid plaques, neurofibrillary tangles and extensive neuronal loss. There is evidence indicating that the increased DNA damages may contribute to neuronal loss in AD. Recently, it has been shown that the capacity of some types of DNA repair is impaired in the neurons of AD patients. A functional polymorphism (Arg194Trp) of X-ray repair...

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Source

Identifiers

PMID: 20553853
DOI: 10.1016/j.jns.2010.05.002

Genes

XRCC1
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of polymorphism of DNA repair gene XRCC1 with sporadic late-onset Alzheimer's disease and age of onset in elderly Han Chinese.PMID 20553853Read ↗

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