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Article

Single nucleotide polymorphisms in base-excision repair genes hOGG1, APE1 and XRCC1 do not alter risk of Alzheimer's disease.

Neuroscience letters - 19 Sept 2008

Parildar-Karpuzoğlu Hande, Doğru-Abbasoğlu Semra, Hanagasi Hasmet A, Karadağ Berrin, Gürvit Hakan, Emre Murat, Uysal Müjdat

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a poorly understood etiology. There is considerable evidence that oxidative stress occurs in AD and increased DNA damage has been found in brain tissues and leukocytes of AD patients. Base excision repair (BER) is the major pathway responsible for removing oxidative DNA damage. Polymorphisms in DNA-repair genes have been associated with the...

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Source

Identifiers

PMID: 18672023
DOI: 10.1016/j.neulet.2008.07.047

Genes

XRCC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Single nucleotide polymorphisms in base-excision repair genes hOGG1, APE1 and XRCC1 do not alter risk of Alzheimer's disease.PMID 18672023Read ↗

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