Article
Spread of vaccine-derived poliovirus from a paralytic case in an immunodeficient child: an insight into the natural evolution of oral polio vaccine.
Journal of virology - 1 Jan 2005
Cherkasova E A, Yakovenko M L, Rezapkin G V, Korotkova E A, Ivanova O E, Eremeeva T P, Krasnoproshina L I, Romanenkova N I, Rozaeva N R, Sirota L, Agol V I, Chumakov K M
Abstract excerpt
Sabin strains used in the manufacture of oral polio vaccine (OPV) replicate in the human organism and can give rise to vaccine-derived polioviruses. The increased neurovirulence of vaccine derivatives has been known since the beginning of OPV use, but their ability to establish circulation in com...
Topics
- Evolution, Molecular
- Genome, Viral
- Humans
- Infant
- Mutation
- Poliomyelitis
- Poliovirus
- Poliovirus Vaccine, Oral
- Recombination, Genetic