Article
Spread of vaccine-derived poliovirus from a paralytic case in an immunodeficient child: an insight into the natural evolution of oral polio vaccine.
Journal of virology - 1 Jan 2005
Cherkasova E A, Yakovenko M L, Rezapkin G V, Korotkova E A, Ivanova O E, Eremeeva T P, Krasnoproshina L I, Romanenkova N I, Rozaeva N R, Sirota L, Agol V I, Chumakov K M
Abstract excerpt
Sabin strains used in the manufacture of oral polio vaccine (OPV) replicate in the human organism and can give rise to vaccine-derived polioviruses. The increased neurovirulence of vaccine derivatives has been known since the beginning of OPV use, but their ability to establish circulation in communities has been recognized only recently during the latest stages of the polio eradication campaign. This important...
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