Article

From Vaccine to Pathogen: Modeling Sabin 2 Vaccine Virus Reversion and Evolutionary Epidemiology

2020-11-04

Abstract excerpt

The oral poliovirus vaccines (OPV) are one of most effective disease eradication tools in public health. However, the Sabin 2 vaccine strain can revert attenuation and cause outbreaks of circulating, vaccine-derived poliovirus (cVDPV2) that are clinically indistinguishable from wild poliovirus (WPV). Accurately assessing cVDP2 risk requires disentangling the complex interaction between epidemiology and evolutionar...

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Literature Corpus work: 0ff6458e-886a-5ec4-9afb-d5a90dd676ed
DOI: 10.1101/2020.11.02.20224634

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