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Altered expression and mutations in cell cycle genes CCND1, CDK4, CDKN2B and TP53 are associated with Pakistani breast cancer patients.

Molecular biology reports - 27 Feb 2026

Tariq Wajeeha, Awan Ali Raza, Mahmood Asim Khalid, Wasim Muhammad

Abstract excerpt

BACKGROUND: Breast cancer impacts nearly one-third of women globally during their lifetime, with the risk increasing in those exhibiting elevated gene expression linked to genetic polymorphisms. In Pakistan, breast cancer ranks among the top 20 leading causes of death, affecting one in every nine women. METHODS AND RESULTS: Gene expression analysis was performed by quantifying mRNA levels of CCND1, CDK4, and...

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Breast Neoplasms
Cyclin D1
Cyclin-Dependent Kinase 4
Gene Expression Regulation, Neoplastic
Genes, cdc

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 41758262
DOI: 10.1007/s11033-026-11610-7

Genes

CCND1
CDK4
CDKN2B
TP53

Variants

rs78130877
rs78130877

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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