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Assessment of Chromosomal DNA Fragmentation by Quinolones in an Isogenic Collection of Escherichia coli with Defined Resistance Mechanisms.

Microbial drug resistance (Larchmont, N.Y.) - 1 Jul 2016

Rodríguez-Martínez José-Manuel, Santiso Rebeca, Machuca Jesús, Bou Germán, Pascual Álvaro, Fernández José Luis

Abstract excerpt

The aim of this study was to investigate the potential usefulness of DNA fragmentation as a quick and simple procedure for detecting resistance to fluoroquinolones (FQ) in isogenic Escherichia coli strains harboring defined and multiple quinolone resistance mechanisms, including low-level quinolone resistance (LLQR) phenotypes. DNA fragmentation assay (Micromax(®)) was evaluated for detecting resistance to FQ in...

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PMID: 26890225
DOI: 10.1089/mdr.2015.0298

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