Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lethal action of quinolones against a temperature-sensitive dnaB replication mutant of Escherichia coli.

Antimicrobial agents and chemotherapy - 1 Jan 2006

Zhao Xilin, Malik Muhammad, Chan Nymph, Drlica-Wagner Alex, Wang Jian-Ying, Li Xinying, Drlica Karl

Abstract excerpt

Inhibition of DNA replication in an Escherichia coli dnaB-22 mutant failed to block quinolone-mediated lethality. Inhibition of protein synthesis by chloramphenicol inhibited nalidixic acid lethality and, to a lesser extent, ciprofloxacin lethality in both dnaB-22 and wild-type cells. Thus, major features of quinolone-mediated lethality do not depend on ongoing replication.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Infective Agents
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chloramphenicol

Share to DNA Helicases

Share to DNA Replication

Share to Escherichia coli

Share to Quinolones

Share to Temperature

Source

Open in PubMed Open full text

Identifiers

PMID: 16377712
DOI: 10.1128/AAC.50.1.362-364.2006
PMCID: PMC1346826

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lethal action of quinolones against a temperature-sensitive dnaB replication mutant of Escherichia coli.PMID 16377712Read ↗

Protein- and RNA-synthesis independent bactericidal activity of ciprofloxacin that involves the A subunit of DNA gyrase.Semantic proximity Read ↗

Lethal fragmentation of bacterial chromosomes mediated by DNA gyrase and quinolones.Semantic proximity Read ↗

The complex of DNA gyrase and quinolone drugs on DNA forms a barrier to the T7 DNA polymerase replication complex.Semantic proximity Read ↗

Lon protease is essential for paradoxical survival of Escherichia coli exposed to high concentrations of quinolone.Semantic proximity Read ↗

Ciprofloxacin does not inhibit mitochondrial functions but other antibiotics doSemantic proximity Read ↗

Identification of temperature-sensitive dnaD mutants of Staphylococcus aureus that are defective in chromosomal DNA replication.Semantic proximity Read ↗

Mechanism of quinolone mutagenicity in bacteria.Semantic proximity Read ↗

DNA gyrase and topoisomerase IV on the bacterial chromosome: quinolone-induced DNA cleavage.Semantic proximity Read ↗

Inhibition of thymidine transport in dnaA mutants of Escherichia coli.Semantic proximity Read ↗

Increase in synthesis and stability of sigma 32 on treatment with inhibitors of DNA gyrase in Escherichia coli.Semantic proximity Read ↗

Properties of a Bacillus subtilis polynucleotide phosphorylase deletion strain.Semantic proximity Read ↗

Inhibitory effects of quinolone antibacterial agents on eucaryotic topoisomerases and related test systemsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.