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Article

The glutathione S-transferase mu polymorphism as a marker for susceptibility to lung carcinoma.

Cancer research - 15 May 1993

Nazar-Stewart V, Motulsky A G, Eaton D L, White E, Hornung S K, Leng Z T, Stapleton P, Weiss N S

Abstract excerpt

Glutathione S-transferase (GST) enzymes detoxify carcinogens in tobacco smoke. Interindividual variation in GST function may be related to differences in risk for smoking-related cancer. Leukocytes from 50% of Caucasians lack GST activity toward trans-stilbene oxide (TSO), due to a deletion of the gene for the GST-mu enzyme. Presence of GST-TSO activity in leukocytes has been associated with low risk for lung...

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PMID: 8485718

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