Article
Genetic variation of basal iron status, ferritin and iron regulatory protein in mice: potential for modulation of oxidative stress.
Biochemical pharmacology - 15 Jan 2000
Clothier B, Robinson S, Akhtar R A, Francis J E, Peters T J, Raja K, Smith A G
Abstract excerpt
Toxic and carcinogenic free radical processes induced by drugs and other chemicals are probably modulated by the participation of available iron. To see whether endogenous iron was genetically variable in normal mice, the common strains C57BL/10ScSn, C57BL/6J, BALB/c, DBA/2, and SWR were examined for major differences in their hepatic non-heme iron contents. Levels in SWR mice were 3- to 5-fold higher than in the...
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