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Article

TRAIL death receptors as tumor suppressors and drug targets

1 Jun 2008

Abstract excerpt

Various ways of targeting TRAIL-death receptors for the treatment of a diverse set of malignancies are being explored in ongoing clinical trials. Recent data of ours and others suggest that loss of the only death signaling receptor in mice (TRAIL-R) is associated with susceptibility to various stages of lymphomagenesis and carcinogenesis, perhaps in a complex cell- and model-specific manner. Myc-overexpressing B...

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PMID: 18469516
DOI: 10.4161/cc.7.11.5975

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