Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dominant negative effects of a Gbeta mutant on G-protein coupled inward rectifier K+ channel.

FEBS letters - 10 Jul 2006

Zhao Qi, Albsoul-Younes Abla M, Zhao Peng, Kozasa Tohru, Nakajima Yasuko, Nakajima Shigehiro

Abstract excerpt

HEK293 cells were transfected with cDNAs for Gbeta1(W332A) [a mutant Gbeta1], Ggamma2, and inward rectifier K+ channels (Kir3.1/Kir3.2). Application of Gbeta1gamma2 protein to these cells activated the K+ channels only slightly. When mu-opioid receptors and Kir3.1/Kir3.2 were transfected, application of a mu-opioid agonist induced a Kir3 current. However, co-expression of Gbeta1(W332A) suppressed this current....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cattle
Share to G Protein-Coupled Inwardly-Rectifying Potassium Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Dominant

Share to GTP-Binding Protein beta Subunits

Share to GTP-Binding Protein gamma Subunits

Share to Rats, Long-Evans

Share to Receptors, Opioid, mu

Source

Identifiers

PMID: 16797547
DOI: 10.1016/j.febslet.2006.06.016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dominant negative effects of a Gbeta mutant on G-protein coupled inward rectifier K+ channel.PMID 16797547Read ↗

Gbeta residues that do not interact with Galpha underlie agonist-independent activity of K+ channels.Semantic proximity Read ↗

Inhibition of an inward rectifier potassium channel (Kir2.3) by G-protein betagamma subunits.Semantic proximity Read ↗

Interaction of G protein beta subunit with inward rectifier K(+) channel Kir3.Semantic proximity Read ↗

A splice variant of the G protein beta 3-subunit implicated in disease states does not modulate ion channels.Semantic proximity Read ↗

Importance of the G protein gamma subunit in activating G protein-coupled inward rectifier K(+) channels.Semantic proximity Read ↗

Mechanisms of dominant negative G-protein alpha subunits.Semantic proximity Read ↗

Blockade of the human ether-a-go-go-related gene potassium channel by ketanserin.Semantic proximity Read ↗

An asymmetric contribution to gamma-aminobutyric type A receptor function of a conserved lysine within TM2-3 of alpha1, beta2, and gamma2 subunits.Semantic proximity Read ↗

Critical determinants of the G protein gamma subunits in the Gbetagamma stimulation of G protein-activated inwardly rectifying potassium (GIRK) channel activity.Semantic proximity Read ↗

Ligand-induced signal transduction within heterodimeric GABA(B) receptor.Semantic proximity Read ↗

Distinct sites on G protein beta gamma subunits regulate different effector functions.Semantic proximity Read ↗

Development of Mutant M3 Muscarinic Receptors Biased for G Protein Activation or Recruitment of β-Arrestins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.