Article
Inhibition of an inward rectifier potassium channel (Kir2.3) by G-protein betagamma subunits.
The Journal of biological chemistry - 13 Dec 1996
Cohen N A, Sha Q, Makhina E N, Lopatin A N, Linder M E, Snyder S H, Nichols C G
Abstract excerpt
The molecular basis of G-protein inhibition of inward rectifier K+ currents was examined by co-expression of G-proteins and cloned Kir2 channel subunits in Xenopus oocytes. Channels encoded by Kir2.3 (HRK1/HIR/BIRK2/BIR11) were completely suppressed by co-expression with G-protein betagamma subunits, whereas channels encoded by Kir2. 1 (IRK1), which shares 60% amino acid identity with Kir2.3, were unaffected....
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