Article
Importance of the G protein gamma subunit in activating G protein-coupled inward rectifier K(+) channels.
FEBS letters - 17 Dec 1999
Kawano T, Chen L, Watanabe S Y, Yamauchi J, Kaziro Y, Nakajima Y, Nakajima S, Itoh H
Abstract excerpt
The G protein-coupled inward rectifier K(+) channel (GIRK) is activated by direct interaction with the heterotrimeric GTP-binding protein betagamma subunits (Gbetagamma). However, the precise role of Gbeta and Ggamma in GIRK activation remains to be elucidated. Using transient expression of GIRK1, GIRK2, Gbeta1, and Ggamma2 in human embryonic kidney 293 cells, we show that C-terminal mutants of Gbeta1, which do...
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