Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A splice variant of the G protein beta 3-subunit implicated in disease states does not modulate ion channels.

Physiological genomics - 16 Apr 2003

Ruiz-Velasco Victor, Ikeda Stephen R

Abstract excerpt

A single-nucleotide polymorphism (C825T) in the GNB3 gene produces an alternative splice variant of the heterotrimeric G protein beta3 subunit (Gbeta3). Translation of the alternatively spliced mRNA results in a protein product, Gbeta3-s, in which 41 amino acids are deleted from Gbeta3. Interestingly, previous studies indicate that the C825T allele occurs with a high frequency in patients with certain vascular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium Channels, N-Type
Share to Fluorescence Resonance Energy Transfer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to G Protein-Coupled Inwardly-Rectifying Potassium Channels

Share to Gene Transfer Techniques

Share to Heterotrimeric GTP-Binding Proteins

Share to Pertussis Toxin

Share to Potassium Channels, Inwardly Rectifying

Share to Vascular Diseases

Source

Identifiers

PMID: 12595577
DOI: 10.1152/physiolgenomics.00057.2002

Genes

GNB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A splice variant of the G protein beta 3-subunit implicated in disease states does not modulate ion channels.PMID 12595577Read ↗

Characterization of the splice variant Gbeta3v of the human G-protein Gbeta3 subunit.Semantic proximity Read ↗

Identification and ethnic distribution of major haplotypes in the gene GNB3 encoding the G-protein beta3 subunit.Semantic proximity Read ↗

G protein beta 3 subunit 825T allele, hypertension, obesity, and diabetic nephropathy.Semantic proximity Read ↗

Association of a human G-protein beta3 subunit variant with hypertension.Semantic proximity Read ↗

G-Protein β3-Subunit Gene C825T Polymorphism and Cardiovascular Risk: An Updated Review.Semantic proximity Read ↗

G-protein beta3 subunit gene (GNB3) variant in causation of essential hypertension.Semantic proximity Read ↗

G protein polymorphisms in hypertension, atherosclerosis, and diabetes.Semantic proximity Read ↗

G-protein beta3 subunit 825T allele and hypertension.Semantic proximity Read ↗

Identification and characterization of G beta 3s2, a novel splice variant of the G-protein beta 3 subunit.Semantic proximity Read ↗

Molecular genetics of G proteins and atherosclerosis risk.Semantic proximity Read ↗

G-protein beta3 subunit gene (GNB3) polymorphism 825C-->T in patients with hypertensive crisis.Semantic proximity Read ↗

The C825T polymorphism in the G-protein beta3 subunit gene and diabetic complications in IDDM patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.