Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional effect of the p22phox -930A/G polymorphism on p22phox expression and NADPH oxidase activity in hypertension.

Hypertension (Dallas, Tex. : 1979) - 1 Aug 2004

San José Gorka, Moreno María U, Oliván Sara, Beloqui Oscar, Fortuño Ana, Díez Javier, Zalba Guillermo

Abstract excerpt

Oxidative stress induced by superoxide is implicated in hypertension. NADPH oxidase is the main source of superoxide in phagocytic and vascular cells, and the p22phox subunit is involved in NADPH oxidase activation. Recently we reported an association of -930A/G polymorphism in the human p22phox gene promoter with hypertension. This study was designed to investigate the functional role of this polymorphism in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Luciferases
Share to Muscle, Smooth, Vascular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NADPH Dehydrogenase

Share to NADPH Oxidases

Share to Nitric Oxide

Share to Phosphoproteins

Share to Rats, Inbred SHR

Share to Rats, Inbred WKY

Source

Identifiers

PMID: 15210651
DOI: 10.1161/01.HYP.0000134790.02026.e4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional effect of the p22phox -930A/G polymorphism on p22phox expression and NADPH oxidase activity in hypertension.PMID 15210651Read ↗

The C242T CYBA polymorphism of NADPH oxidase is associated with essential hypertension.Semantic proximity Read ↗

The effect of p22(phox) -930A/G, A640G and C242T polymorphisms of NADPH oxidase on peripheral and central pressures in healthy, normotensive individuals.Semantic proximity Read ↗

Oxidative stress in arterial hypertension: role of NAD(P)H oxidase.Semantic proximity Read ↗

A novel CYBA variant, the -675A/T polymorphism, is associated with essential hypertension.Semantic proximity Read ↗

C242T polymorphism of the NADPH oxidase p22PHOX gene and its association with endothelial dysfunction in asymptomatic individuals with essential systemic hypertension.Semantic proximity Read ↗

The angiotensin-converting enzyme insertion/deletion polymorphism is associated with phagocytic NADPH oxidase-dependent superoxide generation: potential implication in hypertension.Semantic proximity Read ↗

C242T CYBA polymorphism of the NADPH oxidase is associated with reduced respiratory burst in human neutrophils.Semantic proximity Read ↗

Preliminary characterisation of the promoter of the human p22(phox) gene: identification of a new polymorphism associated with hypertension.Semantic proximity Read ↗

The C242T CYBA polymorphism as a major determinant of NADPH oxidase activity in patients with cardiovascular disease.Semantic proximity Read ↗

Mechanisms of superoxide production in human blood vessels: relationship to endothelial dysfunction, clinical and genetic risk factors.Semantic proximity Read ↗

Functional effects of NAD(P)H oxidase p22(phox) C242T mutation in human leukocytes and association with thrombotic cerebral infarction.Semantic proximity Read ↗

The C242T p22phox polymorphism and endothelium-dependent vasodilation in subjects with hypercholesterolaemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.