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Article

CRTC Potentiates Light-independent timeless Transcription to Sustain Circadian Rhythms in Drosophila.

Scientific reports - 31 Aug 2016

Kim Minkyung, Lee Hoyeon, Hur Jin-Hoe, Choe Joonho, Lim Chunghun

Abstract excerpt

Light is one of the strongest environmental time cues for entraining endogenous circadian rhythms. Emerging evidence indicates that CREB-regulated transcription co-activator 1 (CRTC1) is a key player in this pathway, stimulating light-induced Period1 (Per1) transcription in mammalian clocks. Here, we demonstrate a light-independent role of Drosophila CRTC in sustaining circadian behaviors. Genomic deletion of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27577611
DOI: 10.1038/srep32113
PMCID: PMC5005998

Genes

CLOCK
CRTC1
TIMELESS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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