Article
Assessing the accuracy of ancestral protein reconstruction methods.
PLoS computational biology - 23 Jun 2006
Williams Paul D, Pollock David D, Blackburne Benjamin P, Goldstein Richard A
Abstract excerpt
The phylogenetic inference of ancestral protein sequences is a powerful technique for the study of molecular evolution, but any conclusions drawn from such studies are only as good as the accuracy of the reconstruction method. Every inference method leads to errors in the ancestral protein sequence, resulting in potentially misleading estimates of the ancestral protein's properties. To assess the accuracy of...
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