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Article

Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics.

Nature communications - 11 May 2020

Froning Karen, Maguire Jack, Sereno Arlene, Huang Flora, Chang Shawn, Weichert Kenneth, Frommelt Anton J, Dong Jessica, Wu Xiufeng, Austin Heather, Conner Elaine M, Fitchett Jonathan R, Heng Aik Roy, Balasubramaniam Deepa, Hilgers Mark T, Kuhlman Brian, Demarest Stephen J

Abstract excerpt

Recombinant T cell receptors (TCRs) can be used to redirect naïve T cells to eliminate virally infected or cancerous cells; however, they are plagued by low stability and uneven expression. Here, we use molecular modeling to identify mutations in the TCR constant domains (Cα/Cβ) that increase the unfolding temperature of Cα/Cβ by 20 °C, improve the expression of four separate α/β TCRs by 3- to 10-fold, and...

Read the complete abstract on PubMed

Topics

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Share to Antibodies, Bispecific
Share to Calorimetry, Differential Scanning

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytotoxicity, Immunologic

Share to Polysaccharides

Share to Protein Denaturation

Share to Protein Stability

Share to Receptors, Antigen, T-Cell

Share to Solubility

Source

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Identifiers

PMID: 32393818
DOI: 10.1038/s41467-020-16231-7
PMCID: PMC7214467

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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