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Article

Interaction specificity of clustered protocadherins inferred from sequence covariation and structural analysis.

Proceedings of the National Academy of Sciences of the United States of America - 3 Sept 2019

Nicoludis John M, Green Anna G, Walujkar Sanket, May Elizabeth J, Sotomayor Marcos, Marks Debora S, Gaudet Rachelle

Abstract excerpt

Clustered protocadherins, a large family of paralogous proteins that play important roles in neuronal development, provide an important case study of interaction specificity in a large eukaryotic protein family. A mammalian genome has more than 50 clustered protocadherin isoforms, which have remarkable homophilic specificity for interactions between cellular surfaces. A large antiparallel dimer interface formed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31431536
DOI: 10.1073/pnas.1821063116
PMCID: PMC6731663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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