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Article

Protein-protein interactions; coupling of structurally conserved residues and of hot spots across interfaces. Implications for docking.

Structure (London, England : 1993) - 1 Jun 2004

Halperin Inbal, Wolfson Haim, Nussinov Ruth

Abstract excerpt

Hot spot residues contribute dominantly to protein-protein interactions. Statistically, conserved residues correlate with hot spots, and their occurrence can distinguish between binding sites and the remainder of the protein surface. The hot spot and conservation analyses have been carried out on one side of the interface. Here, we show that both experimental hot spots and conserved residues tend to couple across...

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Identifiers

PMID: 15274922
DOI: 10.1016/j.str.2004.04.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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