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Vaccination against <i>Neisseria meningitidis</i> Using Three Variants of the Lipoprotein GNA1870

17 Mar 2003

Abstract excerpt

Sepsis and meningitis caused by serogroup B meningococcus are devastating diseases of infants and young adults, which cannot yet be prevented by vaccination. By genome mining, we discovered GNA1870, a new surface-exposed lipoprotein of Neisseria meningitidis that induces high levels of bactericidal antibodies. The antigen is expressed by all strains of N. meningitidis tested. Sequencing of the gene in 71 strains...

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PMID: 12642606
DOI: 10.1084/jem.20021911

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