Article
Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells.
Blood - 6 Apr 2017
Schlums Heinrich, Jung Moonjung, Han Hongya, Theorell Jakob, Bigley Venetia, Chiang Samuel C C, Allan David S J, Davidson-Moncada Jan K, Dickinson Rachel E, Holmes Tim D, Hsu Amy P, Townsley Danielle, Winkler Thomas, Wang Weixin, Aukrust Pål, Nordøy Ingvild, Calvo Katherine R, Holland Steve M, Collin Matthew, Dunbar Cynthia E, Bryceson Yenan T
Abstract excerpt
Heterozygous GATA2 mutation is associated with immunodeficiency, lymphedema, and myelodysplastic syndrome. Disease presentation is variable, often coinciding with loss of circulating dendritic cells, monocytes, B cells, and natural killer (NK) cells. Nonetheless, in a proportion of patients carrying GATA2 mutation, NK cells persist. We found that peripheral blood NK cells in symptomatic patients uniformly lacked...
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