Article
An allele-specific, stochastic gene expression process controls the expression of multiple Ly49 family genes and generates a diverse, MHC-specific NK cell receptor repertoire.
European journal of immunology - 1 Aug 1998
Held W, Kunz B
Abstract excerpt
Mouse NK cells express MHC class I-specific inhibitory Ly49 receptors. Since these receptors display distinct ligand specificities and are clonally distributed, their expression generates a diverse NK cell receptor repertoire specific for MHC class I molecules. We have previously found that the D...
Topics
- Alleles
- Animals
- Antigens, Ly
- Base Sequence
- Clone Cells
- DNA Primers
- Gene Expression
- Histocompatibility Antigens Class I
- Killer Cells, Natural
- Lectins, C-Type
- Membrane Glycoproteins
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Multigene Family
- NK Cell Lectin-Like Receptor Subfamily A
- Polymerase Chain Reaction
- Receptors, Immunologic