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Article

Evidence for high bi-allelic expression of activating Ly49 receptors.

Nucleic acids research - 1 Sept 2009

Rouhi Arefeh, Lai C Benjamin, Cheng Tammy P, Takei Fumio, Yokoyama Wayne M, Mager Dixie L

Abstract excerpt

Stochastic expression is a hallmark of the Ly49 family that encode the main MHC class-I-recognizing receptors of mouse natural killer (NK) cells. This highly polygenic and polymorphic family includes both activating and inhibitory receptor genes and is one of genome's fastest evolving loci. The inhibitory Ly49 genes are expressed in a stochastic mono-allelic manner, possibly under the control of an upstream...

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Identifiers

PMID: 19605564
DOI: 10.1093/nar/gkp592
PMCID: PMC2760814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Evidence for high bi-allelic expression of activating Ly49 receptors.PMID 19605564Read ↗

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Evidence for epigenetic maintenance of Ly49a monoallelic gene expression.Semantic proximity Read ↗

Activating Receptor Signals Drive Receptor Diversity in Developing Natural Killer Cells.Semantic proximity Read ↗

Expression of natural killer receptor alleles at different Ly49 loci occurs independently and is regulated by major histocompatibility complex class I molecules.Semantic proximity Read ↗

Genomic Ly49A transgenes: basis of variegated Ly49A gene expression and identification of a critical regulatory element.Semantic proximity Read ↗

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