Article
Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jan 2002
Vance Russell E, Jamieson Amanda M, Cado Dragana, Raulet David H
Abstract excerpt
Natural killer (NK) cells are believed to achieve self-tolerance through the expression of self-MHC-specific inhibitory receptors, such as members of the Ly49 and CD94/NKG2 families. Individual Ly49 genes are stochastically expressed by NK subsets and are expressed in a monoallelic fashion, but little is known about the mechanisms underlying CD94/NKG2A expression. We show here that, like Ly49 genes, mouse Nkg2a...
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